Despite the explosive growth of genomic data, functional annotation of regulatory
sequences remains difficult. Here, we introduce" comparative epigenomics"—interspecies …

Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation
in all organisms. Genetic variation in regulatory regions has been connected with diseases …

Eukaryotic gene transcription is accompanied by acetylation and methylation of
nucleosomes near promoters, but the locations and roles of histone modifications elsewhere …

Linking regulatory DNA elements to their target genes, which may be located hundreds of
kilobases away, remains challenging. Here, we introduce Cicero, an algorithm that identifies …

In order to provide a comprehensive resource for human structural variants (SVs), we
generated long-read sequence data and analyzed SVs for fifteen human genomes. We …

Recent advancements in next-generation sequencing technologies and accompanying
reductions in cost have led to an explosion of techniques to examine DNA accessibility and …

Methods derived from CUT&RUN and CUT&Tag enable genome-wide mapping of the
localization of proteins on chromatin from as few as one cell. These and other mapping …

Recent advances in single-cell technologies have enabled the characterization of
epigenomic heterogeneity at the cellular level. Computational methods for automatic cell …

Non-human primates are attractive laboratory animal models that accurately reflect both
developmental and pathological features of humans. Here we present a compendium of cell …

Despite significant progress in the structural and functional characterization of the human
genome, understanding of the mechanisms underlying the genetic basis of human …