Aims This study explored the associations of genetic susceptibility and adherence to a
healthy lifestyle with incident coronary heart disease (CHD) and stroke in individuals with …

Background: Atherosclerotic cardiovascular diseases (CVDs) are leading causes of death
despite effective therapies and result in unnecessary morbidity and mortality throughout the …

Background Polygenic scores—which quantify inherited risk by integrating information from
many common sites of DNA variation—may enable a tailored approach to clinical medicine …

Assisted reproductive technology (ART) refers to processing gametes in vitro and usually
involves in vitro fertilization. Originally developed for the treatment of infertility, culture of …

Numerous chronic diseases have a substantial hereditary component. Recent advances in
human genetics have allowed the extent of this to be quantified via genome-wide …

Over the last several decades, there has been a considerable growth in type 2 diabetes
(T2DM) in Asians. A pathophysiological mechanism in Asian T2DM is closely linked to low …

Family history is the standard indirect measure of inherited susceptibility in clinical care,
whereas polygenic risk scores (PRSs) have more recently demonstrated potential for more …

Inference of clinical phenotypes is a fundamental task in precision medicine, and has
therefore been heavily investigated in recent years in the context of electronic health records …

Objectives Individuals with more education are at lower risk of developing multiple, different
age-related diseases than their less-educated peers. A reason for this might be that …

Preimplantation genetic testing using polygenic risk scores (PGT-P) has recently been
introduced. However, PGT-P has been met with many ethical concerns. It is therefore …