We conducted a Mendelian randomization analysis to differentiate associations of four
glycemic indicators with a broad range of atherosclerotic and thrombotic diseases …

Observational studies have reported that gastroesophageal reflux disease (GERD) is a risk
factor for cardiovascular diseases (CVD); however, the causal inferences between them …

Background Proteomic profiling may allow identification of plasma proteins that associate
with subsequent changesin kidney function, elucidating biologic processes underlying the …

Background Uromodulin, the most abundant protein excreted in normal urine, plays major
roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of …

The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

Genome-wide association studies (GWASs) have identified thousands of genetic loci
associated with complex traits, including a wide variety of diseases. Despite the successful …

The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …

Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …

Background PUFAs were suggested to be beneficial for kidney function in observational
studies. However, whether these associations are causal remains unclear. Objectives This …

Background While targeted systemic inflammatory modulators show promise in preventing
chronic kidney disease (CKD) progression, the causal link between specific inflammatory …