Schizophrenia is a debilitating psychiatric disorder that affects millions of people worldwide;
however, its etiology is poorly understood at the molecular and neurobiological levels. A …

The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …

Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic
etiology. Despite this, prior attempts to localize susceptibility loci have produced …

Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of
adults. While large-scale genetics studies have identified genomic regions associated with …

Identification of the genetic polymorphisms that contribute to susceptibility for common
diseases such as type 2 diabetes and schizophrenia will aid in the development of …

Deep resequencing of functional regions in human genomes is key to identifying potentially
causal rare variants for complex disorders. Here, we present the results from a large-sample …

Genome-wide association studies (GWASs) have identified over 180 independent
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …

INTRODUCTION Chromosomal conformations, topologically associated chromatin domains
(TADs) assembling in nested fashion across hundreds of kilobases, and other “three …

We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the
association between the disorder and chromosomal copy number (CNV) burden. We …

Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has
demonstrated dysregulation at the molecular level, characterized by transcriptomic and …